8 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... Pernicious anemia/B12 ... respiratory failure • Neurologic ... ) - Waddling gait ... Phosphatase: • Other causes
The Stages of Syphilis 

Primary Syphilis 
- The chancre lesion is the hallmark of primary syphilis.
soles in 50% of cases ... and nephrotic syndrome ... tabes dorsalis, gait ... similar to those of B12 ... Latent #Tertiary #Diagnosis
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
- Causes progressive ... (3) primary lateral ... Hyperreflexia, Increased Jaw ... Lateral #Sclerosis #neurology ... #diagnosis #management
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Epidemiology: • 1-2 cases ... , bradycardia, urinary ... Guillain-Barre Diagnosis ... #diagnosis #management ... #treatment #neurology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
scalp tenderness, jaw ... with GCA or as primary ... affects the skin, neurologic ... Rash, arthritis Primary ... tract, and often causes
Evaluation of Recurrent Falls

Core Concept:
Maintaining an upright posture requires the integrated function of multiple systems.
Disruption in
: Vertigo, imbalance ... e.g., diabetic, B12 ... neuron disease (ALS ... Recurrent #Falls #Diagnosis ... Evaluation #Geriatrics #Neurology
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
Treat underlying cause ... treat - Calcium > 12 ... AML (~20 %) and APL ... fever, weight gain ... Oncology #HemeOnc #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... caused by uncontrolled ... • In all patients ... Types of HLH • Primary ... Emerging therapies: JAK