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management hematology algorithm antibiotics lp pediatrics stepbystep stratification alcohol apml aws differentiation ebm etoh gout hemophagocytic hlh leukostasis lymphohistiocytosis lysis
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... ” an infant with ... CRP < 20 mg/L #Diagnosis ... Management #Pediatrics #Peds ... #Febrile #Infant
The Febrile Infant Step-by-Step Algorithm This is an algorithm developed by European emergency physicians to identify low-risk
The Febrile Infant ... empiric antibiotic treatment ... 92.0% and 46.9% #Diagnosis ... #Febrile #Infant ... Stratification #Fever
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... frequently affects infants ... : HLH signs and ... acute or subacute febrile ... following: • Fever
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... WBC >100k, + lab signs ... : - If febrile ... #TLS #diagnosis ... #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Attempt if high risk ... Subacute-Acute: • Common: fever ... Rare: DAH, acute febrile
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
inflammatory response Risk ... sex • Metabolic syndrome ... -24 Hours • Fever ... double contour sign ... #rheumatology
Alcohol Withdrawal Syndrome (AWS) - ICU OnePager Scoring Alcohol Withdrawal Syndrome (AWS): • PAWSS • CIWA-Ar •
3% - High risk ... Hallucinosis (12 ... with normal vital signs ... instability (low grade fever ... #AWS #diagnosis
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