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diagnosis management neurology msk pathophysiology sclerosis treatment algorithm als amyotrophic arthritis autoantibodies autoimmune behcet brudzinskis chagas clinical complications erythematosus joint
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
Spinal Cord Disorders ... and signs below ... myelopathy - Vit B12 ... Sarcoidosis, Behcet disease ... dysfunction • Abnormal reflexes
Brudzinski’s Sign in Meningitis (first described in 19th century by Dr. Josef Brudzinski) Brudzinski's sign is characterized
Brudzinski’s Sign ... flexion causes spinal ... cord movement and ... an involuntary reflex ... despite severe disease
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 Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
of the spinal cord ... Spasticity - Reflexes ... • Bilateral signs ... and/or symptoms ... management #neurology #differential
Meralgia paresthetica: Pathogenesis and Clinical Findings Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica •
intervertebral disc disease ... gait, strength, reflexes ... superior iliac spine ... pathophysiology #differential ... #diagnosis #signs
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Examination: • UMN signs ... Clonus, Babinski’s sign ... • Lhermitte’s sign ... pupillary defect SIGNS ... Signs and symptoms
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
white matter, spinal ... cord, and basal ... ) Differential Diagnosis ... diagnosis #management #signs ... #symptoms #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Neurological 12% ... autoantibodies #signs ... #symptoms #mimickers ... #differential # ... rheumatology
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
cord regions of ... of UMN and LMN signs ... of UMN and LMN signs ... both UMN and LMN signs ... EMG: LMN Signs in
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Lesions of the spinal ... cord • Inflammatory ... endocrine: Vitamin B12 ... Lack of UMN/LMN signs
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Pain - Arthritis Differential ... peripheral vs axial (spine ... Mechanical/degenerative disorders ... noninflammatory Signs ... constitutional symptoms
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