20 results
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Congenital Diseases ... Wiskott-Aldrich syndrome ... Antibody-mediated hemolysis ... consumption • Vitamin B12 ... Differential #Diagnosis #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... blood loss, Acute hemolysis ... Rebound effect from treatment ... Diagnosis #Algorithm #hematology
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework
LOW RETIC INDEX - ↓ PRODUCTION
 • Vitamin
Causes of Anemia in Cirrhosis ... PRODUCTION • Vitamin B12 ... Destruction: Zieve's syndrome ... anemia, Hemolysis ... Differential #Diagnosis #Hepatology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
ULN R - Renal disease ... Look for gamma gap ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology ... #oncology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... vasculitis - GPA ... Differential #Diagnosis #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... • Coombs (-) hemolytic ... Pseudohyponatremia • ↓anion gap ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Hepatopulmonary Syndrome - Diagnosis and Management Summary
A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... with or without cirrhosis ... ) on room air Treatment ... hepatopulmonary #syndrome ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
vein: Budd-chiari syndrome ... hepatitis: < 1 • Cirrhosis ... • Gilbert's syndrome ... • Hemolysis ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
of cholestatic disease ... Alcoholic liver disease ... hepatitis: < 1 • Cirrhosis ... • Gilbert's syndrome ... #differential #Hepatology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
cells can indicate disease ... microglobulin Treatment ... • Richter’s Syndrome ... Leukemia #diagnosis #workup ... #oncology #hematology