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diagnosis rheumatology lupus oncology sle systemic activation aplastic bacilliformis bartonella behcet cerebritis cns cobalamin deficiency differential fever hemeonc hemophagocytic hlh
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Systemic lupus erythematosus ... consumption • Vitamin B12 ... Differential #Diagnosis #Hematology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Treatment: • ... #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Systemic lupus erythematosus ... with leukopenia, anemia ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... Demyelinating Syndrome ... Cerebrovascular Disease ... cerebritis #diagnosis #management ... #treatment
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
- Parvovirus B19 ... • Parvovirus B19 ... Treatment: ... #oncology #hematology ... #diagnosis #management
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
wt loss • If anemia ... to IBD, celiac disease ... Check for IF ab Treatment ... Deficiency #diagnosis #management ... #nutrition
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myeloproliferative Disease ... Platelet Disorders • Nutritional ... : vitamin B12 or ... factor (GCSF) treatments ... #diagnosis #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome ... oral ulcers in 12 ... Arthritis, AS Treatment ... #diagnosis #management ... signs #symptoms #rheumatology
Oroya Fever Hematologic disease caused by Bartonella bacilliformis Restricted to the Andes highlands of Peru & Ecuador B. bacilliformis:
Oroya Fever Hematologic ... disease caused ... severe hemolytic anemia ... TREATMENT: ​• Acute ... Fever #diagnosis #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Nephrogenic DI Hematologic ... Cryoglobulinemia (4%-12% ... Adenocarcinoma Treatment ... Diagnosis #Management
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