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diagnosis hematology differential management oncology aplastic approach celiac classification cobalamin disease elevatedmcv macrocytic macrocytosis mds myelodysplasia myelodysplastic nutrition syndromes thrombocytosis
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
Fatigue and IBD ... Crohn's > UC Anemia ... restricted diet/deficiency ... /other causes • ... #IBD #Algorithm
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Inflammatory: • IBD ... • Rheumatic disorders ... effect following treatment ... malignancy • Iron deficiency ... anemia #Thrombocytosis
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Differential Diagnosis Algorithm ... • Dietary Deficiency ... • Small Bowel Disorder ... #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Differential Diagnosis Algorithm ... • B12/Folate ... Deficiency • Aplastic ... • RBC Membrane Disorder ... #Causes #Hematology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... dysfunction, and/or disorders ... slowing, neuropathy, fatigue ... diarrhea related to IBD ... Check for IF ab Treatment
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
disease • Iron-deficiency ... anemia unresponsive ... to treatment ... Inflammatory (IBD ... #gastroenterology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever • Fatigue ... and petechiae Causes ... , GATA2 deficiency ... , CTLA4 deficiency ... Treatment:
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... Symptoms: • Fatigue ... Nutritional: vitamin B12 ... or folic acid deficiency ... • Copper deficiency
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