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diagnosis differential hematology management iron oncology aplastic approach ascorbicacid celiac classification cobalamin disease elevatedmcv macrocytic macrocytosis mds myelitis myelodysplasia myelodysplastic
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
Fatigue and IBD ... Crohn's > UC Anemia ... restricted diet/deficiency ... /other causes • ... #IBD #Algorithm
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Inflammation: IBD ... Iron metabolism disorders ... #diagnosis #anemia ... #nutrition
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Pregnancy, EPO treatment ... Loss (without anaemia ... Inflammatory Disease (IBD ... #nutrition
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Differential Diagnosis Algorithm ... • Dietary Deficiency ... • Small Bowel Disorder ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Inflammatory: • IBD ... • Rheumatic disorders ... effect following treatment ... malignancy • Iron deficiency ... anemia #Thrombocytosis
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Differential Diagnosis Algorithm ... • B12/Folate ... Deficiency • Aplastic ... • RBC Membrane Disorder ... #Causes #Hematology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... dysfunction, and/or disorders ... slowing, neuropathy, fatigue ... Check for IF ab Treatment ... diagnosis #management #nutrition
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
disease • Iron-deficiency ... anemia unresponsive ... to treatment ... Inflammatory (IBD ... #gastroenterology
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
Scurvy (Vitamin C Deficiency ... breath, wasting, anemia ... Loss of teeth Anemia ... , or any other cause ... vasculitis Treatment
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