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diagnosis management hemeonc leukemia activation aplastic chronic cll emergencies hemophagocytic hlh lymphocytic lymphohistiocytosis macrophage mas mds myelodysplasia myelodysplastic oncologic rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... recurrent infections/fevers ... - Parvovirus B19 ... Treatment: ... #oncology #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Classified among the secondary ... - Nonremitting fever ... with leukopenia, anemia ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... Nutritional: vitamin B12 ... factor (GCSF) treatments ... #diagnosis #hematology ... #oncology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... : - Fever + ANC ... ): - Hematologic ... stenting - Consider anticoagulation ... treat - Calcium > 12
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... • Neutropenia, anemia ... microglobulin Treatment ... diagnosis #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... • Tumor lysis syndrome ... bone marrow and secondary ... #Leukemia #Hematology ... #Oncology #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... STX11, STXBP2 • Secondary ... - Cytopenias (anemia ... Fever b. ... Diagnosis #Management #Hematology
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