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diagnosis dermatology differential management oncology hemeonc activation acute aplastic emergencies febrile hemophagocytic hiv hlh infectiousdiseases lesions lymphohistiocytosis macrophage mas mds
Fever and Rash - Differential Diagnosis Framework • Viral: Measles, Infectious Mono (EBV, CMV), Acute HIV,
Fever and Rash - ... HIV, Parvovirus B19 ... Meningococcal meningitis, Secondary ... #Rash #Differential ... #Diagnosis #dermatology
ID Approach to Fever and Rash - Diagnostic Algorithm Central Maculopapular (most common): Measles, Parvovirus 819 / EBV,
and Rash - Diagnostic ... Algorithm Central ... (PPGSS), Secondary ... angiomatosis, Sweet syndrome ... #Rash #Febrile
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... recurrent infections/fevers ... - Parvovirus B19 ... Treatment: ... #oncology #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Classified among the secondary ... Petechial or purpuric rash ... with leukopenia, anemia ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
Figure 4, page 12 ... vasculitic diseases secondary ... petechiae/purpura with fever ... #Diagnosis #Dermatology ... Purpural #Purpuric #Rash
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... Nutritional: vitamin B12 ... factor (GCSF) treatments ... marrow studies Treatment ... #diagnosis #hematology
Pustular Skin Lesions - Differential Diagnosis Framework What are pustules? • Pustules < 5-10 mm + pus • Material
Generalized itchy rash ... psoriasis (GPP) 12 ... SAPHO syndrome ( ... Pustules + Fever ... Secondary syphilis
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
: - Fever + ANC ... ): - Hematologic ... stenting - Consider anticoagulation ... treat - Calcium > 12 ... , rash, hypoxia,
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Headache (45%) • Fever ... (28%) • Skin rash ... enzymes ↑ • Mild anemia ... detecting HIV for 10-12 ... antibody test) Treatment
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... STX11, STXBP2 • Secondary ... - Cytopenias (anemia ... Fever b. ... Diagnosis #Management #Hematology
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