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diagnosis differential management hemeonc leukemia causes chronic cll lymphocytic pancytopenia signs algorithm aplastic atrophicglossitis b1 candida cobalamin copper emergencies encephalopathy
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... Platelet Disorders • Nutritional ... : vitamin B12 or ... #diagnosis #hematology ... #oncology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Vitamins and Vitamin Deficiency ... Wernicke-Korsakoff syndrome ... gestation • Vitamin B12 ... diagnosis #signs #symptoms ... #nutrition
Risk Factors and Signs of Copper Deficiency Risk Factors: • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
Signs of Copper Deficiency ... diarrhoea, Short bowel syndrome ... dental fixatives, Treatment ... , Leucopenia, Neutropenia ... #riskfactors #symptoms
Wernicke Encephalopathy - Acute B1 (Thiamine) Deficiency - Diagnosis and Management Diagnosis - Caine Criteria (2 of
Anorexia nervosa Treatment ... Encephalopathy • A prompt treatment ... can improve symptoms ... development of Korsakoff syndrome ... (chronic B1 deficiency
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
• Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12 ... Differential #Diagnosis #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Difficulty breathing • Neutropenia ... , GATA2 deficiency ... Treatment: ... • Improve the symptoms ... #oncology #hematology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... to manifest its symptoms ... , alcohol use, symptoms ... Check for IF ab Treatment ... diagnosis #management #nutrition
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
of anemia or thrombocytopenia ... PRCA, autoimmune neutropenia ... marrow failure with anemia ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
hypertension and/or drug treatment ... , Kostmann syndrome ... Megaloblastic anemia-rare ... - Copper deficiency-rare ... diagnosis #causes #hematology
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