5794 results
Approach to Neonatal Jaundice

Causes of pathologic hyperbilirubinemia can be classified as due to (1) increased bilirubin
(1) increased bilirubin ... , (2) impaired bilirubin ... or (3) impaired bilirubin ... #Diagnosis #Peds
Jaundice Differential Diagnosis: A short guide

By Dr. Khudhur Mohammed @khudhur_moh

#jaundice #gastroenterology #algorithm #differential #diagnosis #hyperbilirubinemia #bilirubin
Jaundice Differential Diagnosis ... #differential #diagnosis ... hyperbilirubinemia #bilirubin
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
birth with serum bilirubin ... associated with bilirubin ... in conjugated bilirubin ... in conjugated bilirubin ... #hepatology #diagnosis
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
predominantly indirect bilirubin ... • Increased bilirubin ... ) • Impaired bilirubin ... Faulty excretion of bilirubin ... Classification #diagnosis
Liver Function Tests (LFTs)
 - Aspartate aminotransferase (AST) 
 - Alanine aminotransferase (ALT) 
 - Alkaline
transpeptidase (GGT) - Bilirubin ... LFTs #Laboratory #Diagnosis
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Unconjugated bilirubin ... Testing #workup #diagnosis
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Phosphatase and Bilirubin ... initial insult Bilirubin ... transports conjugated bilirubin ... ASTALT #AlkPhos #Bilirubin ... Pathophysiology #Diagnosis
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Hemolysis - Diagnostic ... Increased Serum bilirubin ... Workup #Hematology #Diagnosis
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
in bone Total bilirubin ... TBili) Direct bilirubin ... Indirect bilirubin ... Interpretation #diagnosis
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
fold elevation, Bilirubin ... fold elevation, Bilirubin ... but variable ++, Bilirubin ... #differential #diagnosis