111 results
Jaundice Differential Diagnosis: A short guide

By Dr. Khudhur Mohammed @khudhur_moh

#jaundice #gastroenterology #algorithm #differential #diagnosis #hyperbilirubinemia #bilirubin
Jaundice Differential ... khudhur_moh #jaundice ... hyperbilirubinemia #bilirubin
Approach to Neonatal Jaundice

Causes of pathologic hyperbilirubinemia can be classified as due to (1) increased bilirubin
Approach to Neonatal Jaundice ... (1) increased bilirubin ... , (2) impaired bilirubin ... or (3) impaired bilirubin ... Pediatrics #Neonatal #Jaundice
Bilirubin metabolism and pathophysiology of jaundice 

#Bilirubin #metabolism #pathophysiology #jaundice #hepatology
Bilirubin metabolism ... pathophysiology of jaundice ... #Bilirubin #metabolism ... pathophysiology #jaundice
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice ... • Increased bilirubin ... ) • Impaired bilirubin ... postoperative jaundice ... neoplasms #Jaundice
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
breastfeeding jaundice ... and breastmilk jaundice ... manifest only as jaundice ... birth with serum bilirubin ... associated with bilirubin
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Hepatitis - Onset of jaundice ... before the onset of jaundice ... - Serum total bilirubin ... days of onset of jaundice
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
) • Onset of jaundice ... before the onset of jaundice ... • Serum total bilirubin ... days of onset of jaundice
Abnormally Colored Urine - Differential Diagnosis Framework
Red:
 - Hematuria, Hemoglobinuria, Myoglobinuria
 - Beets, Rhubarb, Blackberries, Artificial
Dehydration, Increased bilirubin ... Chronic obstructive jaundice
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Pruritus, Mild jaundice ... fold elevation, Bilirubin ... fold elevation, Bilirubin ... but variable ++, Bilirubin
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
hyperpigmentation • Jaundice ... slightly elevated • Bilirubin