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Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
fever syndromes Clinical ... Fever is the main clinical ... ↑ AST ↑ ALT ↑ bilirubin ... Treatment: • Corticosteroids
Bilirubin Metabolism - Pathophysiology • Conjugated Bilirubin • Unconjugated Bilirubin By Dr. Khushboo Gala @LouLectures #Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... • Conjugated Bilirubin ... • Unconjugated Bilirubin ... LouLectures #Bilirubin
Biochemistry and Metabolism of Bilirubin Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
Metabolism of Bilirubin ... → Unconjugated Bilirubin ... "indirect bilirubin ... and "indirect" bilirubin ... interchangeably for routine clinical
Bilirubin Crystals on Urine Microscopy Dr. Telma Lemos @TELMALEMOS10 #Bilirubin #Crystals #crystalluria #Urine #Microscopy #trichomoniasis #clinical
Bilirubin Crystals ... TELMALEMOS10 #Bilirubin ... trichomoniasis #clinical
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 Approach to Neonatal Jaundice Causes of pathologic hyperbilirubinemia can be classified as due to (1) increased bilirubin
(1) increased bilirubin ... , (2) impaired bilirubin ... or (3) impaired bilirubin
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
as jaundice on clinical ... birth with serum bilirubin ... associated with bilirubin ... in conjugated bilirubin ... in conjugated bilirubin
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
haptoglobin ↑ indirect bilirubin ... diagnosis #management #treatment
Jaundice Differential Diagnosis: A short guide By Dr. Khudhur Mohammed @khudhur_moh #jaundice #gastroenterology #algorithm #differential #diagnosis #hyperbilirubinemia #bilirubin
hyperbilirubinemia #bilirubin
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Phosphatase and Bilirubin ... initial insult Bilirubin ... transports conjugated bilirubin ... ASTALT #AlkPhos #Bilirubin
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
weeks • Typical clinical ... fold elevation, Bilirubin ... post-partum • Typical clinical ... fold elevation, Bilirubin ... but variable ++, Bilirubin
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