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diagnosis causes nephrology hepatology endocrinology dermatology management workup hematology pediatrics secondary hypercalcemia hyponatremia liver peds cardiology hypokalemia metabolic obgyn pbc
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Primary Biliary ... Cirrhosis - Pathophysiology ... gradual loss of bile ... Cholestasis #PBC #Primary ... #Pathophysiology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... 65 years PBC Pathophysiology ... No extrahepatic biliary ... ducts Differential ... #Biliary #Cirrhosis
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... Diagnosis Algorithm ... - Drugs - Primary ... biliary Cholangitis ... diseases/Bile duct
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis #pathophysiology #pbc #psc #hepatology #comparison
Liver Disease: Primary ... Biliary Cirrhosis ... vs Primary Sclerosing ... Cholangitis #pathophysiology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Liver Enzymes - Differential ... Diagnosis Algorithm ... Duct Stone • Biliary ... #LiverEnzymes #Differential ... #Diagnosis #Algorithm
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Hepatomegaly - Differential ... Diagnosis Algorithm ... Biliary Cirrhosis ... #Hepatomegaly #Differential ... #Diagnosis #Algorithm
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Jaundice - Differential ... Diagnosis Algorithm ... on Ultrasound Biliary ... Gallstones • Biliary ... Cholangiocarcinoma • Primary
Hypophosphatemia - Measurement of urine phosphate excretion - Differential Diagnosis Algorithm • GI loss • Redistribution
phosphate excretion - Differential ... Diagnosis Algorithm ... deficiency • Primary ... phosphate #excretion #Differential ... #Diagnosis #Algorithm
Mechanism of Action of Bile Acid Sequestrants Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Mechanism of Action of Bile ... Sequestrants Bile ... Pool → ↑ Hepatic Bile ... Plasma LDL-C #biliary ... sequestration #pathophysiology
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
Causes of Ascites - Differential ... Diagnosis Algorithm ... liver failure • Primary ... biliary cholangitis ... • Primary sclerosing
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