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diagnosis hepatology differential lfts liver cbd clinical pbc primary ultrasound bileduct cholangitis abnormal ascariasis cirrhosis dilated elevation transaminitis workup acid
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... Drugs - Primary biliary ... PSC - Other biliary ... diseases/Bile duct ... Differential #Diagnosis #Algorithm
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
the liver ALP - Biliary ... tree or bile flow ... Transaminase >> Alkaline ... Cholestatic Pattern - Alkaline
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... 65 years PBC Pathophysiology ... PBC Labs: • Alkaline ... No extrahepatic biliary ... malignancy #Primary #Biliary
Mechanism of Action of Bile Acid Sequestrants Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Mechanism of Action of Bile ... Sequestrants Bile ... Pool → ↑ Hepatic Bile ... Plasma LDL-C #biliary ... sequestration #pathophysiology
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Primary Biliary ... Cirrhosis - Pathophysiology ... gradual loss of bile ... inflammation and biliary ... #PBC #Primary #Biliary
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Tests - AST, ALT, Alkaline ... within liver Alkaline ... stimulated by bile ... bilirubin into bile ... Bilirubin #Hepatology #Pathophysiology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Differential Diagnosis Algorithm ... US - Dilated Bile ... Ducts • Common Bile ... Duct Stone • Biliary ... Differential #Diagnosis #Algorithm
Amyloidosis - Workup and Diagnostic Algorithm • Serum Immunofixation and Serum Free Light Chains • Biopsy
and Diagnostic Algorithm ... Biopsy Surrogate Site ... • CBC, CMP, alkaline ... Workup #Diagnosis #Algorithm
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Differential Diagnosis Algorithm ... • US - Normal Bile ... • US - Dilated Bile ... - CBD stone, Biliary ... Transaminitis #Algorithm
Common Bile Duct Stone on POCUS Here’s a similar case in a 70yo F with a remote
Common Bile Duct ... Stone on POCUS ... This time on pocus ... Choledocholithiasis #POCUS ... clinical #ultrasound #biliary
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