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management differential hematology signs rheumatology pathophysiology syndromes infectiousdiseases algorithm causes criticalcare hemeonc hepatology infections leukemia nephrology abscess activetb acute aids
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
- Differential Diagnosis ... • Spontaneous bleeding ... of breath • Neurologic ... neutrophil count < 500 cells ... #differential #diagnosis
Lung Abscess Microbiology: • Polymicrobial • Anaerobes (most common) Clinical: • Indolent symptoms that evolve
Lung Abscess Microbiology ... • Indolent symptoms ... , hemoptysis Treatment ... #Abscess #Diagnosis ... #Pulmonary #Clinical
Sarcoidosis Non-caseating granulomas (Composed of T-helper & inflammatory cells) Clinical: • Disease fatal in 10% of
) Clinical: ... exertion • Neurologic ... #Sarcoidosis #Diagnosis ... #Symptoms #Signs ... #Pulmonary
Fat Embolism Syndrome Trauma to the long bone or pelvis accounts for —9096 of cases. The diagnosis
Trauma to the long ... bone or pelvis ... onset widespread pulmonary ... FES is a clinical ... #Symptoms
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... develop leukostasis syndrome ... • Tumor lysis syndrome ... Leukemia #Hematology #Oncology ... #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia Clinical ... ecchymoses, mucosal bleeding ... • Improve the symptoms ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... Simultaneous clotting and bleeding ... “big & sticky” cells ... renal failure, pulmonary ... #HemeOnc #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... unusual bruising or bleeding ... are caused by bleeding ... #diagnosis #hematology ... #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Imaging: CXR- pulmonary ... : >3 symptoms, or ... management #hematology #oncology
Refeeding Syndrome Overview What Is It? • Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
Refeeding Syndrome ... may cause severe clinical ... overload) Other Symptoms ... hyperparathyroidism Treatment ... #Differential #Diagnosis
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