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diagnosis management oncology differential activetb latenttb leukemia lymphoma syndrome tb tuberculosis algorithm apml atlas cancer causes chronic classification cll coagulation
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
type (B cell, T cells ... natural killer (NK) cells ... Hepatosplenomegaly, cytopenias(bleeding ... • Other hematologic ... #differential #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
number of sites of disease ... Lymphoma Treatment ... cycles without XR ... ABVD x 2 cycles + XR ... classification #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
anemia, Liver diseases ... , Liver diseases ... , Bleeding gastric ... PD deficiency, Pulmonary ... #differential #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemopathies+++: Hodgkin ... • Autoimmune diseases ... Adult-onset Still disease ... Unknown cause Treatment ... #summary #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
identical to the non-Hodgkin ... can indicate disease ... microglobulin Treatment ... PML leukemia, Hodgkin ... workup #oncology #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Schistocytes, helmet cells ... • Severe Liver Disease ... Treatment: ... diagnosis #causes #treatment ... #management #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Symptoms: • Malaise, bleeding ... extramedullary disease ... night sweats, bleeding ... manifestations, hypoxia, CXR ... #Leukemia #Hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Release from blast cells ... common • Imaging: CXR ... - pulmonary opacities ... diagnosis #management #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
: • 10%-15% Pulmonary ... Nephrogenic DI Hematologic ... Malignancy Risk: • Non-Hodgkins ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
involvement - seeding ... and Culture • CXR ... Tuberculosis Treatment ... Initiating Treatment ... • Check CXR and
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