15 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... night sweats, bleeding ... manifestations, hypoxia, CXR ... • Significant bleeding ... #Hematology #Oncology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
anemia, Liver diseases ... , Liver diseases ... , Bleeding gastric ... PD deficiency, Pulmonary ... #differential #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
involved) • No leukemic ... type (B cell, T cells ... Hepatosplenomegaly, cytopenias(bleeding ... Lymphomas • Other hematologic ... #differential #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Skin: - CLL cells ... or basket cells ... can indicate disease ... microglobulin Treatment ... workup #oncology #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
promyelocytic leukemia ... • Severe Liver Disease ... Treatment: ... diagnosis #causes #treatment ... #management #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Chronic Lymphocytic Leukemia ... • Most common leukemia ... lymphocytes, smudge cells ... chemotherapy for low-risk disease ... #oncology #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Release from blast cells ... common • Imaging: CXR ... - pulmonary opacities ... diagnosis #management #hematology
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
involvement - seeding ... and Culture • CXR ... Tuberculosis Treatment ... Initiating Treatment ... • Check CXR and
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are caused by bleeding ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... Myeloproliferative Disease ... Syndromes #diagnosis #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
ecchymoses, mucosal bleeding ... number of CD34+ cells ... virus (EBV) • Leukemia ... aplastic anemia Treatment ... Anemia #oncology #hematology