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differential management hematology cardiology symptoms table clinical elevation emergencies hemeonc leukemia mds myelodysplastic oncologic pathophysiology pharmacology renal rheumatology syndromes vasculitis
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
- Differential Diagnosis ... Hyperviscosity Syndrome ... • Spontaneous bleeding ... neutrophil count < 500 cells ... #differential #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... old, ~10,000 new cases ... #Management #treatment ... #hematology #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... unusual bruising or bleeding ... by bleeding (petechiae ... #diagnosis #hematology ... #oncology
Fat Embolism Syndrome Trauma to the long bone or pelvis accounts for —9096 of cases. The diagnosis
Fat Embolism Syndrome ... the long bone or pelvis ... accounts for —9096 of cases ... onset widespread pulmonary ... #Diagnosis #Signs
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
ecchymoses, mucosal bleeding ... and petechiae Causes ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... Leukemia #Hematology #Oncology ... #Diagnosis
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia If prolonged or ≥ 39 C this is a
Treatment depends ... maintained fever CAUSES ... hyperthermia crisis (late sign ... amphetamines) Toxic: • Radiologic ... Anesthesia #Checklist #Diagnosis
Refeeding Syndrome: Pathogenesis and clinical findings Patients at Risk of Refeeding Syndrome: - Little or no nutritional
PO4& Mg prior to feeding ... - CHF - Pulmonary ... PO4 and Mg into cells ... #diagnosis #pathophysiology ... #symptoms #signs
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Syndromes - OnePager ... Renal Syndromes ... Goodpasture's cause ... leading to diffuse ... #management #treatment
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Release from blast cells ... Imaging: CXR- pulmonary ... management #hematology #oncology
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