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diagnosis hematology differential tls cardiology lysis table activetb algorithm cancer latenttb leukemia mds myelodysplastic pharmacology renal syndromes tb tuberculosis anemia
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Hyperviscosity Syndrome ... • Spontaneous bleeding ... neutrophil count < 500 cells ... EMERGENCIES: Tumor ... Lysis Syndrome:
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Classification of Tumor ... Lysis Syndrome ... #TumorLysis #Syndrome ... TLS #diagnosis #management ... #oncology
Tumor Lysis Syndrome - Workup and Management Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... - Workup and Management ... of the above Treatment ... #Lysis #Syndrome ... #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... only curative treatment ... #treatment #hematology ... #oncology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Myelodysplastic syndrome ... Stomatocytes - Malignant tumors ... Liver diseases, Bleeding ... PD deficiency, Pulmonary ... Hemolytic uremic syndrome
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
organ damage • Treatment ... cells releasing ... Low calcium • Treatment ... - Hyperkalemia treatment ... TLS #diagnosis #management
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... malignancies Treatments ... #Lysis #Syndrome ... #TLS #oncology ... #management #UricAcid
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
night sweats, bleeding ... develop leukostasis syndrome ... Fibrinolysis & DIC • Tumor ... lysis syndrome: ... Leukemia #Hematology #Oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
unusual bruising or bleeding ... are caused by bleeding ... factor (GCSF) treatments ... marrow studies Treatment ... diagnosis #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... ecchymoses, mucosal bleeding ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... hematology #diagnosis #management
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