11 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Tyrosine Kinase activity ... develop leukostasis syndrome ... Fibrinolysis & DIC • Tumor ... lysis syndrome: ... Leukemia #Hematology #Oncology
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Immunosuppression • Tumor ... involvement - seeding ... Tuberculosis Treatment ... TB #Diagnosis #Management ... #Treatment #ActiveTB
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Immunosuppression • Tumor ... involvement - seeding ... Tuberculosis Treatment ... TB #Diagnosis #Management ... #Treatment #ActiveTB
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Constitutional Syndromes ... ecchymoses, mucosal bleeding ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... hematology #diagnosis #management
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
antibiotics TLS (tumor-lysis ... Simultaneous clotting and bleeding ... interventional radiology ... “big & sticky” cells ... renal failure, pulmonary
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Imaging: CXR- pulmonary ... APML #diagnosis #management ... #hematology #oncology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
predominant HL - The tumor ... • PET scan - activity ... Hodgkin Lymphoma Treatment ... classification #hematology #oncology ... #management
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
with presence of pulmonary ... causing hypovolemia needing ... acute coronary syndrome ... differential #algorithm #management ... #cardiology #treatment
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Disease: • 10%-15% Pulmonary ... , INC risk PE, Pulmonary ... Adenocarcinoma Treatment ... muscarinic agonists • Active ... Rheumatology #Diagnosis #Management
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... increase in CD4+ cells ... • Persistently active ... #Inflammatory #Syndrome ... Differential #Diagnosis #Management