25 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... normal - Hemolysis, NASH ... #Patterns #Liver ... #Injury #hepatology ... transaminitis #differential
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure (ACLF) Clinical ... Alcohol-Associated Hepatitis ... (DILI) Viral Hepatitis ... Procedures Management ... Failure #Cirrhosis #Hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Check Acute viral hepatitis ... disease: > 2 • NASH ... RBC (hemolysis, bleeding ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... disease: > 2 • NASH ... RBC (hemolysis, bleeding ... #differential # ... diagnosis #algorithm #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
infiltration) Differential ... Diagnosis: Viral Hepatitis ... Maternal Support - Critical ... #Pregnancy #hepatology ... obgyn #diagnosis #management
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... arthritis, Skin rash ... fraction < 20% Differential ... hepatomegaly, hepatitis ... Disease #diagnosis #management
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
disease to acute liver ... hepatocellular pattern of liver ... (eg Viral) Management ... AIH #Diagnosis #Management ... #Hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
weeks • Typical clinical ... post-partum • Typical clinical ... Disease #Pregnancy #hepatology ... #obstetrics #hepatitis ... #comparison #differential
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
Hypertension - Differential ... >10 mmHg - clinically ... Cirrhosis/acute hepatitis ... sarcoidosis) • Liver ... metastasis • Fatty liver
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
purpura to mucosal bleeding ... Petechial or purpuric rash ... thrombocytopenia • Liver ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology