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diagnosis hepatology algorithm differential hyperbilirubinemia management antibody aplastic autoimmune congenital conjugated hemolytic hepatitis inherited injury liver oncology rheumatology thromboticthrombocytopenicpurpura treatment
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
DIAGNOSE AIHA • Anemia ... bilirubin, ↑ LDH ... autoantibodies: positive direct ... 2) LOOK FOR a cause ... management #treatment #rheumatology
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
non-ICU vs ICU causes ... Hyperbilirubinemia #direct ... #bilirubin #Differential ... Diagnosis #Algorithm #gastroenterology ... #hepatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
decrease in most cases ... result in severe anemia ... immune hemolytic anemia ... Indirect bilirubin ... Diagnosis #Workup #Hematology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
and stress may cause ... the blood • Defect ... • Defect in secretion ... #hepatology #diagnosis ... #gastroenterology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... Mechanisms: • Direct ... ecchymoses, mucosal bleeding ... and petechiae Causes ... #oncology #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... Half-life: 1 week • Direct ... bilirubin: ↑ ... RBC (hemolysis, bleeding ... diagnosis #algorithm #hepatology
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