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diagnosis differential hepatology oncology liver algorithm amyloidosis bariatric bypass chemistry complications congenital emergencies gastric hemeonc hepatitis hyperbilirubinemia inherited injury interpretation
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
Conjugation == Gilbert Syndrome ... hyperbilirubinemia syndrome ... and stress may cause ... #hepatology #diagnosis ... #gastroenterology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... purpura to mucosal bleeding ... ↑ AST ↑ ALT ↑ bilirubin ... MAS #Macrophage #Activation ... #Management #Hematology
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
: • Nephrotic syndrome ... failure • GI bleeding ... Carpal tunnel syndrome ... Inflammation → Macrophage activation ... hypoadrenalism • Nausea
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
week • Direct bilirubin ... as neoplasm or amyloid ... RBC (hemolysis, bleeding ... • Gilbert's syndrome ... #differential #Hepatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
CML (Chronic Myeloid ... -> AML: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... vein: Budd-chiari syndrome ... • Gilbert's syndrome ... RBC (hemolysis, bleeding ... diagnosis #algorithm #hepatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... by bleeding (petechiae ... , or all three myeloid ... Out Secondary Causes ... #diagnosis #hematology
Complications after Bariatric Surgery Post Bariatric Intestinal Failure: • Severe protein malnutrition after bariatric surgery • More
Consider refeeding syndrome ... deficiencies) Dumping Syndrome ... inuslin release leading ... Gastric bypass causes ... and Hepatology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
TLS (tumor-lysis syndrome ... ): - Hematologic ... Simultaneous clotting and bleeding ... Treat underlying cause ... Leukostasis: - Usually myeloid
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