10 results
diagnosis differential hepatology hemolysis liver management algorithm antibody aplastic autoimmune chemistry congenital extravascular fever hepatitis hyperbilirubinemia infectiousdiseases inherited injury interpretation
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... ) Morphology Atlas ... Liver diseases, Bleeding ... uremic syndrome ... #differential #hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
AIHA • Anemia ... haptoglobin ↑ indirect bilirubin ... ↑ LDH • Anti-RBC ... 2) LOOK FOR a cause ... management #treatment #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... • Intrinsic RBC ... differential #diagnosis #hematology ... #anemia
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... - Unconjugated Bilirubin ... Differential #Diagnosis #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... vein: Budd-chiari syndrome ... • Gilbert's syndrome ... : RBC (hemolysis ... , bleeding, hematoma
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
result in severe anemia ... schistocytes, nucleated RBCs ... anemia Indirect ... bilirubin - Mild-to-moderate ... Diagnosis #Workup #Hematology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
Inherited Non-hemolytic ... without evidence of hemolysis ... and stress may cause ... #hepatology #diagnosis ... #gastroenterology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
: RBC (hemolysis ... , bleeding, hematoma ... (hemolysis) • ... • Gilbert's syndrome ... #differential #Hepatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
ecchymoses, mucosal bleeding ... and petechiae Causes ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... #oncology #hematology
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
region Viral Syndromes ... ; dengue shock syndrome ... aminotransferase and bilirubin ... No hemolytic anemia ... Investigations: • CBC
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