29 results
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
Conjugation == Gilbert Syndrome ... syndrome • An ... and stress may cause ... #hepatology #diagnosis ... #gastroenterology
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Unconjugated hyperbilirubinemia ... posthepatitis hyperbilirubinemia ... reactions) Conjugated hyperbilirubinemia ... miscellaneous causes ... #differential #causes
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm

1. Definition: T.bili elevation + >20% conjugated
2. Obtain RUQ
to Conjugated Hyperbilirubinemia ... non-ICU vs ICU causes ... #direct #bilirubin ... Diagnosis #Algorithm #gastroenterology ... #hepatology
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
- Unconjugated Hyperbilirubinemia ... • Gilbert's Syndrome ... Crigler-Najjar Syndromes ... Diagnosis #Algorithm #Causes ... #Hepatology #bilirubinemia
Causes of Small Bowel Bleeding - Differential Diagnosis
Common Causes:
 • Under age 40 years: Inflammatory Bowel
Causes of Small ... Bowel Bleeding - ... Diagnosis Common Causes ... #SmallBowel #Bleeding ... #gastroenterology
Disorders of the Hepatic and Mesenteric Circulation

Platelets in Cirrhosis
Hypercoagulability in Cirrhosis
Bleeding in Cirrhosis
Portal Vein Thrombosis (PVT)
Mesenteric
in Cirrhosis Bleeding ... ) Budd Chiari Syndrome ... Circulation #Disorders #Hepatology ... #Gastroenterology
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
and hepatorenal syndrome ... function: INR, bilirubin ... Post-Hepatic: • Cardiac causes ... • Budd Chiari syndrome ... #hepatology
Causes of Biliary Dilatation - Differential Diagnosis
 • Physiological: ↑ Age, Cholecystectomy, Opioid dependence, Post-sphincterotomy
 •
Causes of Biliary ... sludge), Mirizzi's syndrome ... Biliary #Dilatation #causes ... differential #diagnosis #hepatology ... #gastroenterology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
IL-1 and IL-6, leading ... purpura to mucosal bleeding ... ↑ AST ↑ ALT ↑ bilirubin ... Diagnosis #Management #Hematology ... #Rheumatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Algorithm Vascular Causes ... vein: Budd-chiari syndrome ... • Gilbert's syndrome ... RBC (hemolysis, bleeding ... diagnosis #algorithm #hepatology