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diagnosis erythematosus management systemic algorithm antinuclear differential sle activation anemia antibodies antiphospholipid aplastic apls autoantibodies bruising cancer cerebritis classification cns
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Systemic lupus ... Clinical Presentation ... SJIA], systemic lupus ... Diagnosis #Management #Hematology ... #Rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic Lupus ... Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... inflammation, leading ... CNS #neurology #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... , Drug-induced Lupus ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... #patterns #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Non-autoimmune rheumatologic ... Clinical Features ... vein thrombosis Hematologic ... Erythematosus #Diagnosis #Rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
searched for when ANA ... -15% If SLE is clinically ... SLE-SSc-AlM overlap syndromes ... erythematosus #diagnosis #rheumatology ... #table #ANA
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... lupus anticoagulant ... von Willebrand syndrome ... • Lupus anticoagulant ... Differential #Diagnosis #Hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... Hyperviscosity Syndrome ... : • Clinical triad ... (e.g. systemic lupus ... classification #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Paradoxical spontaneous bleeding ... Biopsy: Typical pathologic ... Antiphospholipid syndrome ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Aplastic Anemia Clinical ... ecchymoses, mucosal bleeding ... Constitutional Syndromes ... Anemia #oncology #hematology
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
Helpful Clinical ... surgical procedures and ... and skin haemorrhage ... Marfan syndrome, ... pediatrics #diagnosis #hematology
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