11 results
Switching Between Anticoagulants and DOACs
VKA, Dabigatran, Rivaroxaban, Apixaban, Edoxaban, Betrixaban, DOAC, Parenteral anticoagulant

DOI: 10.1161/JAHA.120.017559

#Anticoagulants #DOACs #anticoagulation
and DOACs VKA, ... Dabigatran, Rivaroxaban ... , Apixaban, Edoxaban ... , Betrixaban, DOAC ... #Switching #hematology
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... #DOAC #Bridging ... Anticoagulation #Dabigatran ... #Apixaban #Rivaroxaban ... #Pharmacology #Hematology
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet
Novel (or Direct) Oral Anti-Coagulants
 • Rivaroxaban
 • Apixaban
NOAC / DOAC Pharmacology ... Rivaroxaban • Apixaban ... • Dabigatran ... #Prescribing #hematology ... #Direct #Oral #AntiCoagulant
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Anticoagulants Common ... Protamine sulfate - Dabigatran ... (Praxbind) - Apixaban ... anticoagulation #doac ... #hematology #reversal
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
DOAC: Cheat Sheet ... Renal Dosing: Apixaban ... patients 5mg bid Dabigatran ... Anticoagulation #Hematology ... #Pharmacology #Apixaban
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... treatment; volume ... Antidotes: • Apixaban ... modified factor Xa • Dabigatran ... #hematology #management
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
algorithm for the treatment ... direct-acting oral anticoagulants ... body mass index; VTE ... #DOAC #VTE #Malignancy ... Anticoagulation #Management #Hematology
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
for VTE in Malignancy ... risk of recurrent VTE ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... Anticoagulation #Management #Hematology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
interruption per treatment ... and procedural bleeding ... with a very low bleeding ... of Therapy • Dabigatran ... inhibitor) • Apixaban
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
) Cancer-treatment ... rivaroxaban, and apixaban ... Rivaroxaban and apixaban ... Dabigatran has moderate ... Chemotherapy #Oncology #Hematology