12 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... Blast cells - Blood ... blast cells - Blood ... -> AML: Blast crises ... #Hematology #Oncology
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
promyelocytic leukemia ... (blood). ... features in most cases ... promyelocytic #leukemia ... #Hematology #Clinical
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- History of bleeding ... epistaxis, gingival bleeding ... plateletcount), peripheral blood ... not required in all ... #Workup #hematology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
the total white blood ... Myeloproliferative Disorders ... (CML) - associated ... Chickenpox Other Causes ... #hematology #basophils
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... caused by blood ... transformation to AML ... • Hairy Cell Leukemia ... Syndromes #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... lymphoproliferative disorders ... Lymphocytosis: Absolute blood ... Transform to DLBCL, PML ... workup #oncology #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
promyelocytic leukemia ... ABO incompatible blood ... organ damage Clinical ... Treat primary cause ... treatment #management #hematology
Hematology Algorithms 

Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... proportion of the red blood ... three peripheral blood ... well as varying clinical ... These causes could
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
which can plug blood ... Paradoxical spontaneous bleeding ... cryoglobulinemia Associated Disorders ... cryoglobulins • Negative causes ... #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia Clinical ... and petechiae Causes ... virus (EBV) • Leukemia ... result from low blood ... Anemia #oncology #hematology