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diagnosis differential management causes leukemia product reactions algorithm approach atlas calculation chronic classification cll index key lymphocytic mds morphology myelodysplasia
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... result from low blood ... #Anemia #oncology ... #hematology #diagnosis
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm Blood ... Reticulocytes • Iron Deficiency ... • B12/Folate Deficiency ... • Aplastic Anemia ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Microcytic - Iron-deficiency ... Liver diseases, Bleeding ... cells - G-6-PD deficiency ... #differential #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
the peripheral blood ... deficiencies: Iron deficiency ... marrow failure: Aplastic ... , G6PD deficiency ... Production #Index #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
unusual bruising or bleeding ... • Aplastic Anemia ... or folic acid deficiency ... Syndromes #diagnosis #hematology ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... Blast cells - Blood ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... Pure red cell aplasia ... diagnosis #workup #oncology ... #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... recipients w/ IgA deficiency ... due to marrow aplasia ... coagulopathy & ↑bleeding ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
recipients w/ IgA deficiency ... Injury (TRALI): Leading ... due to marrow aplasia ... coagulopathy & ↑bleeding ... diagnosis #management #hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
Megaloblastic anemia-rare ... - Copper deficiency-rare ... including white blood ... cell aplasia DOI ... diagnosis #causes #hematology
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