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diagnosis causes hemolytic dermatology cold extravascular hemolysis intravascular mds myelodysplasia myelodysplastic nonpalpable oncology palpable petechiae petechial physicalexam rash syndromes testing
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... to platelet disorders ... /Quantity: • Primary ... Diagnosis #hematology ... #rheumatology #
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... (CVID, WAS), (neurologic ... hematologic disorder ... #Platelet #Disorders ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Myelogenous Leukemia • Primary ... • Rheumatic disorders ... • Celiac disease ... Iron deficiency anemia ... #Causes #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... Primary hematological ... Metastatic Disease ... #Workup #Differential ... #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... Primary hematological ... Metastatic Disease ... #Workup #Differential ... #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
15% of AIHA Primary ... Secondary Cold ... Agglutinin Disease ... younger pts) Differential ... #anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
with or without platelet ... Agglutination - Cold agglutinins ... Schistocytes, thrombocytopenia ... Consider RBC membrane disorder ... #workup #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
purpura (TTP), ... usually IgM) (e.g. primary ... cold agglutin disease ... lymphoproliferative disorders ... #diagnosis #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Abnormalities in primary ... or secondary hemostasis ... : - Thrombocytopenia ... - Abnormal platelet ... deficiency Work
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... DDX: Rule Out Secondary ... Myeloproliferative Disease ... blood count with differential ... Syndromes #diagnosis #hematology
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