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systemic thrombocytosis pruritus agglutinin classification cold common cvid extravascular hemolysis hodgkins hypogammaglobulinemia immunology intravascular lymphoma mds myelodysplasia myelodysplastic naildisorders nonpalpable
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... • Rheumatic disorders ... • Celiac disease ... Diagnosis #Algorithm ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
usually IgM) (e.g. primary ... lymphoproliferative disorders ... G6PD deficiency) ... #differential # ... diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... malignancies • Anemia ... , hemolysis, hemorrhage ... #Diagnosis #Causes ... #hematology #secondary
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Differential Diagnosis ... and Primary Causes ... #secondary #systemic ... #generalized #dermatology ... Diagnosis #Algorithm
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
/Quantity: • Primary ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... #Diagnosis #hematology ... #nonpalpable #dermatology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary ... Diagnosis Algorithm ... #dermatology #Differential ... #Diagnosis #Algorithm ... #causes
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... anemia Onycholysis ... #dermatology #Differential ... #Diagnosis #Algorithm ... #causes
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
15% of AIHA Primary ... Agglutinin Syndrome ... Diagnosis: • hemolytic ... #hemolytic #anemia ... #hematology #diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... → Refer to hematology ... , deficiency anemia ... #Diagnosis #Algorithm ... #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... anemia) • Systemic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
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