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hematology diagnosis management clinical oncology anemia aplastic chronic cll idsa lymphocytic myelodysplastic opportunistic pharmacology prevention syndrome acanthocytes algorithm arm atrophicglossitis
Prolymphocytes In our case, the patient has T-prolymphocytic leukemia (T-PLL) not Acute Myeloid Leukemia (AML). 🔬Tumor
🔬Tumor cells are ... size lymphoid cells ... Prolymphocytes #Smear ... #Peripheral #Pathology ... #Microscopy #Clinical
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
lymphocytes/Mature B cell ... weeks without infection ... • Peripheral smear ... : Smudge cells or ... microglobulin Treatment
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
Plasma cell leukemia ... primary plasma cell ... Crane, MD, PhD ... formation #Clinical #Smear ... #Hematology #Pathology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Peripheral Smear ... Chronic Myelogenous Leukemia ... Leukemia • Idiopathic ... • Parvovirus infection ... Peripheral blood smear
Beautiful acanthocytes/spur cells in a patient with McLeod Syndrome. X-linked disorder characterized by reduced expression of
acanthocytes/spur cells ... expression of Kell ... Michael Moravek, MD ... McLeod #Syndrome #Smear ... #Pathology #Microscopy
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... risk-stratification • Risks: infection ... transformation to acute leukemia ... Allogeneic stem cell ... Myelodysplastic #Syndrome #MDS
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
• Peripheral smear ... lymphocytes, smudge cells ... Complications: 1) Infection ... Transformation to large cell ... Lauren Banaszak, MD
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
: • Recurrent infections ... megaloblastic anemia Treatment ... Consider stem cell ... Can progress to MDS ... or acute leukemia
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
hematopoietic stem cells ... number of CD34+ cells ... cellularity + dysplastic cells ... number of CD34+ cells ... Number of CD34+ cells
Neoplastic plasma cells with nucleoli (left image) and intranuclear Dutcher body (right image). Dutcher bodies are round,
Neoplastic plasma cells ... Kyle Bradley, MD ... #Intranuclear #Pathology ... #Clinical #Smear ... #Microscopy #PlasmaCells
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