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diagnosis differential algorithm management transaminitis aclf alcoholic chronic cirrhosis druginduced elevated failure gap gastroenterology globulin hematology lfts patterns protein proteingap
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... for alternative causes ... Hepatocellular: Viral infections ... dechallenge • Acute ... #Liver #Injury
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... Parenchyma • Infectious ... , E, B, D, EBV, ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Coagulation Failure Infections ... Injury (DILI) ... Viral Hepatitis ... Failure #Cirrhosis #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Algorithm Vascular Causes ... of Acute Liver ... • Infectious: HAV ... #injury #hepatitis
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Diagnosis • Infectious ... Trauma: Shock liver ... • Iatrogenic: DILI ... Differential #Diagnosis #causes ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... > 20x normal - Acute ... 10-20x normal - Infection ... (EBV/CMV), Alcoholic ... #Injury #hepatology
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
exclude other causes ... - Screen for infection ... kidney injury with ... HCV, DILI, HCC, ... Management #Algorithm #hepatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Include: • Viral infections ... (acute HIV, HBV ... , EBV, VZV, hepatitis ... Sarcoidosis) • Liver ... inflammation (acute
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