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diagnosis differential clinical management algorithm rhabdomyolysis rheumatology causes comparison myopathy nephrology signs symptoms treatment dermatomyositis muscle myopathies myositis neurology pathophysiology
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Creatine kinase (CK ... CK may increase ... creatine kinase (CK ... CK functions as ... CK has a half-life
RHABDOMYOLYSIS • Characterized by skeletal muscle breakdown & necrosis. • Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. • Defined based
Creatine kinase (CK ... Defined based on CK ... • Half-life of CK ... and cefdinir #CK
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Causes of Elevated CK ... Levels Acute CK ... ASYMPTOMATIC: Macro CK ... Kinase #Elevated #CK
Myositis and Myopathies #ESR #CK #Differential diagnosis of myopathy #Inflammatory #myopathies #Dermatomyositis #muscle weakness #Polymyositis #Inclusion body myositis #Polymyalgia rheumatica #Fibromyalgia #Hypothyroid myopathy #Muscle stiffness #Drug-induced
Myopathies #ESR #CK
Rhabdomyolysis - McMahon risk prediction score Using this prediction model, patients with a score < 5 were
score #nephrology #ck
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
weakness • Elevated CK ... rash • Elevated CK ... Elevated ESR, Normal CK ... mildly elevated CK ... Myositis: elevated CK
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Weakness, Normal CK ... Weakness, Incr CK ... therapy), Normal CK
Usmle step 2 ck Pulmonary diseases (High yield points) #usmle #algorithm
Usmle step 2 ck
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
: Proximal • CK ... : Proximal • CK ... : Proximal • CK ... and distal • CK
SMARCB1-deficient sinonasal carcinoma: high grade tumors with varying proportions of basaloid and plasmacytoid/rhabdoid cells; CK+, SMARCB1
rhabdoid cells; CK
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