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Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... antiphospholipid syndrome ... Hypocomplementemia #Low #Complement
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Hyperviscosity Syndrome ... 20% Sjögren's syndrome ... • Low serum C4 complement
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
dysmorphic RBC, RBC casts ... staining (lg + complement ... MGPN • Complement ... of alternative complement ... anti-phospholipid syndrome
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Mucocutaneous lymph node syndrome ... VASCULITIS: • Behçet Syndrome ... • Cogan Syndrome ... against MPO • Complement
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Pulmonary Renal Syndromes ... anti-GBM) 10%: - Low Complement ... Antiphospholipid Syndrome ... Vasculitis - Normal Complement ... differentiation syndrome
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Causes of Hemolytic ... Antibody/DAT+ - Complement ... Differential #Diagnosis #Causes
Causes of Erythema Nodosum - Mnemonic NO cause found in 60% of cases Drugs (antibiotics e.g., sulfonamides, amoxicillin) Oral
Causes of Erythema ... Mnemonic NO cause ... found in 60% of cases ... Sarcoidosis or Lofgren's syndrome ... Nodosum #Mnemonic #Causes
Hyperthermic Syndromes - This table summarizes the similarities and differences between some toxicologic causes of hyperthermic
Hyperthermic Syndromes ... some toxicologic causes ... of hyperthermic syndromes ... • Serotonin syndrome ... #Hyperthermic #Syndromes
Causes of Metabolic Alkalosis - Differential Diagnosis Chloride depletion syndromes • Gastrointestinal losses -
Causes of Metabolic ... Chloride depletion syndromes ... • Liddle syndrome ... administration Other causes ... Differential #Diagnosis #Causes
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... but in severe cases ... Nephritic #Nephrotic #Syndromes
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