16 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Post-strep GN, Lupus ... differential #diagnosis #algorithm ... #rheumatology
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm
 • Reactive (Inflammatory / Infectious)
 •
Causes of Diffuse ... Differential Diagnosis Algorithm ... Metastatic) #Diffuse ... #Focal #Localized ... #Causes #Hematology
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... Post/pauci immune glomerulonephritis ... S - Systemic Lupus ... Hypocomplementemia #Low #Complement ... #differential #hematology
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm

DIFFUSE
Scarring - Irreversible-biopsy required
 • Lupus
Diagnosis Algorithm ... Irreversible-biopsy required • Lupus ... • Discoid lupus ... #Alopecia #dermatology ... #causes
Lupus Nephritis Primer
Class I - Minimal Mesangial
Class II - Mesangial Proliferative
Class Ill - Focal Proliferative
Class IV
Lupus Nephritis ... Proliferative Class Ill - Focal ... Proliferative Class IV - Diffuse ... Nephritis #SLE #Classification ... #Classes #differential
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... Differential Diagnosis Algorithm ... • Systemic Lupus ... Hodgkin's Lymphoma #Diffuse ... #Causes #Hematology
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
severity (ISN/RPS classification ... by 12 months Classification ... • Class Ill - Focal ... • Class IV - Diffuse ... glomeruli) Diffuse
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Allergen-specific lgE causes ... chain causing local ... Post-streptococcal glomerulonephritis ... , Systemic lupus ... allergy #table #classification
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
- Local and systemic ... Complement activation ... Post-streptococcal glomerulonephritis ... , and systemic lupus ... Hypersensitivity #Types #Classification
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... Malignancy (e.g. hematologic ... pneumonitis • Diffuse ... enteropathy, and diffuse