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diagnosis differential nephrology rheumatology aki acute allergy hypersensitivity management reactions sle table vasculitis comparison druginduced emergency glomerular hematuria injury kidneyinjury
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Post-strep GN, Lupus ... • Limited to Kidney ... differential #diagnosis #algorithm
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... , type 1 (50%-80% ... ), type II (80-90% ... S - Systemic Lupus ... Hypocomplementemia #Low #Complement
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... Post-streptococcal glomerulonephritis ... , and systemic lupus ... #Classification
Lupus Nephritis Classification Algorithm #Lupus #Nephritis #Classification #Algorithm #diagnosis #differential #types #rheumatology #nephrology #renal
Lupus Nephritis ... Classification Algorithm ... #Lupus #Nephritis ... #Classification ... #differential #types
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Allergen-specific lgE causes ... they activate complement ... Post-streptococcal glomerulonephritis ... , Systemic lupus ... allergy #table #classification
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Causes of Acute ... Kidney Injury (AKI ... Differential Diagnosis Algorithm ... Acute Kidney Injury ... Rapidly Progressive Glomerulonephritis
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
Type III Hypersensitivity ... self-antigens are the cause ... : • Systemic Lupus ... antigens are the cause ... Post-infectious glomerulonephritis
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
Rapidly Progressive Glomerulonephritis ... ) - Loss of kidney ... IgA nephropathy, lupus ... autoAb against type ... #RPGN #Classification
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... Differential Diagnosis Algorithm ... IgA, post-strep, lupus ... • Lupus glomerulonephritis ... #Causes
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Skin ulcers - Glomerulonephritis ... • Low serum C4 complement ... (e.g. systemic lupus ... #classification
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