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diagnosis management rheumatology differential nephrology classification nephritis table types vasculitis allergy causes comparison druginduced hematology hypersensitivity reactions sle acute aki
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive Glomerulonephritis ... staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Membranoproliferative glomerulonephritis ... Post/pauci immune glomerulonephritis ... S - Systemic Lupus ... Hypocomplementemia #Low #Complement
Approach to managing Glomerulonephritis (GN) in children. ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
Approach to managing Glomerulonephritis ... SLE, systemic lupus ... #Glomerulonephritis ... #Algorithm #Nephrology
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Differential Diagnosis Algorithm ... IgA, post-strep, lupus ... • Lupus glomerulonephritis ... Post-Infectious glomerulonephritis ... Differential #Diagnosis #Algorithm
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... 90% - Low complement ... constitutional symptoms • Treatment ... 80% - Low complement ... life-threatening • Treatment
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... 80% - Low complement ... life-threatening • Treatment ... Lupusreference #SLE #lupus
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Differential Diagnosis Algorithm ... Rapidly Progressive Glomerulonephritis ... IgA, post-strep, lupus ... legionella) • Immune (lupus ... Differential #Diagnosis #Algorithm
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... Post-streptococcal glomerulonephritis ... , and systemic lupus
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
antigens, leading to complement ... they activate complement ... Post-streptococcal glomerulonephritis ... , Systemic lupus
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Necrotizing glomerulonephritis ... , pauci-immune glomerulonephritis ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement
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