5945 results
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
- Differential Diagnosis ... ANCA Associated Vasculitis ... anti-GBM) 10%: - Low Complement ... - Normal Complement ... #Differential #Diagnosis
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... #differential #diagnosis
ANCA-Associated Vasculitis
A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated Vasculitis ... , small-vessel vasculitis ... Complement levels ... ANCA #Associated #Vasculitis ... PANCA #MPO #PR3 #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitis and Vasculitides ... - Differential Diagnosis ... Differential Diagnosis ... against MPO • Complement ... differential #diagnosis
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... Activation of complement ... Leukocytoclastic vasculitis ... #HSP #IgA #Vasculitis ... Pathophysiology #Diagnosis
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Labs/Diagnosis: ... • Low serum C4 complement ... • IgA vasculitis ... • Vasculitis ... Cryoglobulins #diagnosis
Causes of ileitis beyond Crohn’s disease and infections include systemic disorders -spondyloarthropathies, vasculitides, ischemia, and amyloidosis
spondyloarthropathies, vasculitides ... helpful paper complements ... articles/PMC2914216/ #Diagnosis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Differential Diagnosis ... ANCA-associated vasculitis ... RNP antibodies, Complement ... Erythematosus #Diagnosis
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Diagnosis: • hemolytic ... Differential Diagnosis ... temperatures by fixing complement ... anemia #hematology #diagnosis
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
or alternative complement ... for ANCA-related vasculitis ... testing #workup #diagnosis