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diagnosis differential complications sle symptoms algorithm classification erythematosus glomerulonephritis management manifestations mucocutaneous musculoskeletal myelitis neurology progressive rapidly rpgn systemic transverse
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Manifestations • Immune Complex ... Myopathy (Also caused ... Erythematosus #SLE #MSK ... Complications #pathophysiology ... #signs #symptoms
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... immunofluorescence Immune Complex ... Post-strep GN, Lupus ... Glomerulonephritis #Vasculitis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... inflammation (complex ... Livedo Reticularis, Vasculitis ... Manifestations #pathophysiology ... #diagnosis #signs
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tracts Immune Complex ... tract, and often causes ... such as systemic lupus ... purpura: strong sign ... differential #diagnosis #rheumatology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... • Bilateral signs ... • Infectious causes ... virus - Herpes simplex ... - Sjogren - Vasculitis
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