9 results
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
) Pathophysiology ... Active TB: • HIV ... • HIV: 2/3 pulmonary ... TST or IGRA HIV ... : • HIV-infected
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
) Pathophysiology ... Active TB: • HIV ... • HIV: 2/3 pulmonary ... TST or IGRA HIV ... : • HIV-infected
Neurological Manifestations of Tuberculosis
Spinal Arachnoiditis & Polyradiculopathy:
 • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
(IRIS): • In HIV ... Worsening of previous neurologic ... lymphadenopathy, pulmonary ... Children with pulmonary ... differential #TB #neurology
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Neoplastic / Hematologic ... Endocarditis • Tuberculosis ... Hepatitis • HIV ... Chronic Obstructive Pulmonary ... Disease Neurologic
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
reactivation of latent ... status, and focal neurologic ... 80% sensitive Tuberculous ... - Hemorrhage, tuberculomas ... InfectiousDiseases #Neurology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... : 2 hit mechanism ... ARDS to explain symptoms ... , and CXR with pulmonary ... Transfusion #Reactions #hematology
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Mycobacterium tuberculosis ... Advanced HIV (CD4 ... Hematologic malignancy ... gastrointestinal symptoms ... • Clinical (Symptoms
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... Imaging: CXR- pulmonary ... Diagnosis: >3 symptoms ... • Steroids: IV ... diagnosis #management #hematology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Presentation: Systemic Symptoms ... affects the skin, neurologic ... • Progressive symptoms ... cognitive impairment, neurologic ... Differential #Diagnosis #Rheumatology