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diagnosis differential rheumatology erythematosus ophthalmology sle systemic blurry causes classification edema facial hematology management monoclonal monocular oncology paraproteinemias signs sjogrens
Blurry Vision - Differential Diagnosis Framework Anatomical Approach to Eye Disease: 1. Lids/Lashes 2. Extraocular Muscles/Motility 3. Conjunctiva/Sclera 4. Cornea 5. Anterior
Approach to Eye Disease ... Ocular Adverse Effects ... retinal vein occlusion ... - Retinal vein ... retinal vein occlusion
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Others: • Lupus ... : • Behçet Syndrome ... gastrointestinal, and/or central ... • Cogan Syndrome ... such as systemic lupus
Facial Swelling - Differential Diagnosis Framework for Facial Edema Infectious: • Dental abscess • Ludwig's angina • Vincent's angina • Cellulitis •
Adult-onset Still's disease ... Trauma: • Ocular ... internal jugular vein ... : • Morbihan disease ... Differential #Diagnosis #PhysicalExam
Transient Monocular Vision loss - Differential Diagnosis Ischemia - Large artery disease (atherothrombosis, embolus, dissection). -
- Large artery disease ... optic neuropathy, vasculitis ... ) Retinal vein ... Ocular causes - ... floaters obscuring central
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Erythematous, macular ... ANCA-associated vasculitis ... APLA/LAC: • Renal ... artery or vein ... thrombosis • Pelvic vein
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... (SLE) General: ... Butterfly rash, Vasculitis ... Demyelinating syndromes ... disease (30%):
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
pulmonary and renal ... Angiitis of the Central ... • Behcet syndrome ... gastrointestinal, and/or central ... • Cogan syndrome
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... Vasculitis) Autoantibodies ... to cold IgG • Lupus ... Sneddon-Wilkinson disease ... , retinal, DVT,
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... gland) biopsy • Ocular ... Involvement: • Central ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis
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