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diagnosis differential infectiousdiseases causes infections fungal lung cardiology comparison endocarditis management radiology aspergillus betadglucan biomarkers candida candidemia clinical cns crypto
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
• India ink - "Negative ... polysaccharide capsule of Cryptococcus ... detection for cryptococcal ... mucopolysaccharide capsule of Cryptococcus ... #microbiology #microscopy
Causes of Culture Negative Abscess - Differential Diagnosis Framework Consider prior antibiotics as a cause of a
Abscess - Differential ... culture Brain: ... : Aspergillus, Cryptococcus ... nocardia - Fungal: Cryptococcus ... Coccidiomycosis, Cryptococcus
Differential Diagnosis for Concurrent Brain and Lung Infections • Bacteria: Strep anginosus, Staph aureus, Klebsiella pneumoniae
Diagnosis for Concurrent ... Brain and Lung ... Mucormycosis, Cryptococcus ... @ID_fellows #Brain ... Lung #Infections #Concurrent
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... Mucormycosis, Cryptococcus ... febrilepodcast #Brain ... Lung #Infections #Concurrent
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... Mucormycosis, Cryptococcus ... febrilepodcast #Brain ... Lung #Infections #Concurrent
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
histoplasmosis, cryptococcus ... Syphilis • Pyogenic Abscess ... RingEnhancing #Lesions #Brain
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Coccidioides - Negative ... : Cryptococcus, ... Paecilomyces, Cryptococcus ... - Negative: ... decreased with: concurrent
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
• Coagulase-negative ... Aspergillus • Cryptococcus ... suggests perivalvular abscess ... annular or aortic abscess ... Complications: Abscess
Invasive Fungal Infection (IFI) Invasive fungal infections are severe infections in which fungal pathogens invade normally sterile
pulmonary infections) Cryptococcus ... Diagnosis Culture and microscopy ... galactomannan, cryptococcal ... or drainage of abscesses
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Fluconazole CRYPTOCOCCUS ... level, presence of cryptococcal ... CSF and serum Cryptococcal ... • Sinusitis • Brain ... abscess • Disseminated
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