50 results
Algorithm for the Evaluation and Management of Sickle Cell Crises
Clinical Manifestations and Management

#Diagnosis #Management #Hematology #SickleCell
Algorithm for the Evaluation ... Management of Sickle Cell ... Crises Clinical ... Manifestations #Workup ... #Algorithm #Ddxof
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
can indicate disease ... • Neutropenia, anemia ... microglobulin Treatment ... ’s lymphoma or acute ... Leukemia #diagnosis #workup
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, CLL Acute leukemias ... ALL (Acute Lymphoblastic ... extramedullary disease ... - infiltrates (anemia ... ) CLL Symptoms:
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... , CLL, lymphoma, ... Hemoglobinopathies (e.g. sickle cell ... Extravascular #Causes
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
Algorithm for the evaluation ... RBC = red blood cell ... the most likely cause ... recovery also causes ... of the initial work-up
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... formed or don’t work ... Out Secondary Causes ... Myeloproliferative Disease ... Workup: • Complete
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
Manifestations of Sickle Cell ... Disease Acute ... sickle cell hepatic ... Supportive with treatment ... hepatomegaly and anemia
Features of a Sickle Cell Crisis 
Sickle-cell disease - an autosomal recessive blood disorder.
Characterized by red
Crisis Sickle-cell ... disease - an autosomal ... Sickle cell disease ... 2) Aplasia - Acute ... of the baseline anaemia
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... lupus cases, drug-dependent ... • Immunologic Workup ... • Immunologic Workup ... : Chronic disease
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
Causes of False ... RBC turnover • Acute ... • Hemolytic anemia ... Splenomegaly, Sickle Cell ... End-stage renal disease