47 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... Microangiopathic hemolytic anemia ... usually IgG) (e.g. lupus ... Extravascular #Causes ... #differential #
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Platelet Disorders - Differential ... Diagnosis and Workup ... PT, aPTT(liver disease ... changes), high MCV anemia ... - Bone marrow evaluation
Differential Diagnosis and Evaluation of Hyponatremia:
1) Identification of onset (acute vs. chronic)
2) Presence of symptoms (HA,
and Evaluation ... Identification of onset (acute ... symptoms (HA, nausea ... , liver, renal disease ... #Algorithm #Ddxof
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
Disease Acute ... sickle cell hepatic ... Supportive with treatment ... hepatomegaly and anemia ... hepatology #hepatitis #differential
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
during medical evaluation ... or workup for specific ... /µL Workup • Screen ... glucocorticoid treatment ... Disorders #Algorithm #Differential
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
can indicate disease ... • Neutropenia, anemia ... microglobulin Treatment ... ’s lymphoma or acute ... Leukemia #diagnosis #workup
Diffuse Acute Abdominal Pain (<72 hours) - Differential Diagnostic Algorithm
Look for surgical abdomen
Upper quadrant: R/O cardiac,
Diffuse Acute Abdominal ... (<72 hours) - Differential ... musculoskeletal causes ... Ketoacidosis) • Sickle cell ... anemia • Musculoskeletal
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
Causes of False ... RBC turnover • Acute ... • Hemolytic anemia ... Splenomegaly, Sickle Cell ... End-stage renal disease
Interstitial Lung Diseases (ILD)
Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): 
 • Hypersensitivity pneumonitis, Farmer's lung, Bird
ILD caused by inhalation ... Polymyositis-dermatomyositis, Lupus ... Pulmonary Langerhans cell ... ILD #diagnosis #differential ... #pulmonary #causes
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... formed or don’t work ... Myeloproliferative Disease ... Workup: • Complete ... blood count with differential