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hematology algorithm differential chronic management oncology causes cll kawasaki lymphocytic pediatrics workup abdominal b12 cancer carcinoma cbc cobalamin criteria deficiency
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Chronic Myelogenous Leukemia ... disorders • Celiac ... disease Tissue ... Iron deficiency anemia
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... Headaches, bone pain, fever ... - infiltrates (anemia ... #Hematology #Oncology ... #Diagnosis
Chronic Abdominal Pain Causes - Differential Diagnosis Framework Many patients with chronic abdominal pain have had prior
have had prior evaluations ... Red Flags: • Fever ... infarction • Lymphoma/Leukemia ... bowel syndrome • Celiac ... poisoning • Celiac
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Tissue damage • Leukemia ... • Autoimmune diseases ... tachycardia or fever ... count on initial evaluation ... neutrophil #WBC #CBC #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... phenomenon CLL Diagnosis ... cells can indicate disease ... • Neutropenia, anemia ... #diagnosis #workup
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... ) B symptoms → fevers ... chemotherapy for low-risk disease ... #oncology #hematology ... #hemeonc #diagnosis
Algorithm for the Evaluation of Kawasaki and Incomplete Kawasaki Disease: Diagnosis * Fever >5d * Criteria (4/5) -
Algorithm for the Evaluation ... : Diagnosis * ... Fever >5d * Criteria ... #Peds #Pediatrics ... Workup #Algorithm #Ddxof
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary Clinical features - Classic triad (flank pain, hematuria,
Carcinoma (RCC) - Diagnosis ... Anemia (common) ... flank pain (CLOT COLIC ... night sweats, fever ... with contrast Evaluation
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
related to IBD, celiac ... disease, other ... total body stores Evaluation ... consider other diagnosis ... e.g. leukemia
Evaluation of suspected incomplete Kawasaki Disease 1. AHA consensus recommendations 2. Infants ≤6 months old on day ≥7
Evaluation of suspected ... incomplete Kawasaki Disease ... old on day ≥7 of fever ... Albumin ≤3.0 g/dL, anemia ... #Diagnosis #Peds
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