12 results
Algorithm for the Evaluation and Management of Sickle Cell Crises
Clinical Manifestations and Management

#Diagnosis #Management #Hematology #SickleCell
Algorithm for the Evaluation ... Management #Diagnosis ... #Management #Hematology ... Manifestations #Workup ... #Algorithm #Ddxof
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... • Immunologic Workup ... life-threatening • Treatment ... Lupusreference #druginduced ... #diagnosis #management
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... for workup, including ... Rebound effect from treatment ... Vasculitides, IBD, Celiac ... Glucocorticoids, IL
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
during medical evaluation ... or workup for specific ... glucocorticoid treatment ... #Differential #diagnosis ... #hematology #eosinophilia
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE) - Diagnosis ... of SLE versus DIL ... • Immunologic Workup ... Positive in 60-80% of cases ... life-threatening • Treatment
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
) - Stepwise Diagnosis ... non-essential drug/HDS treatments ... for alternative causes ... #DrugInduced #Liver ... #Algorithm #hepatology
Drug Induced Lupus (DIL)
 • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
• Immunologic Workup ... • Evolution: ... Lupusreference #DrugInduced ... #Lupus #DIL #rheumatology ... #diagnosis #treatment
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Fibrinogen level, ↑ sIL ... Drugs, Unknown cause ... Treatment: • ... inhibitors under evaluation ... #management #treatment
Esophageal Variceal Bleeding - Diagnosis and Management Summary
PRE-ENDOSCOPY
Vasoactive agents - Octreotide: 
 • 50mcg bolus →
Variceal Bleeding - Diagnosis ... Goal Hgb 7-9 g/dL ... unclear source (in case ... TIPS • Pre-TIPS evaluation ... #Management #treatment
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... with isolated del ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology