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differential algorithm management thrombocytosis b12 cobalamin disorders druginduced gap gastroenterology gastrointestinal globulin iron lupus mds myelodysplasia myelodysplastic nutrition oncology platelet
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... disorders • Celiac ... disease Tissue ... malignancy • Iron deficiency ... anemia #Thrombocytosis
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
Gastrointestinal Evaluation ... with anemia, diagnose ... tests Test for celiac ... disease with serology ... #Evaluation #workup
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
for workup, including ... Acute hemolysis, deficiency ... anemia, Rebound ... Vasculitides, IBD, Celiac ... disease, Kawasaki
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... changes), high MCV anemia ... - Bone marrow evaluation ... #Causes #Workup
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory Evaluation ... hallmark for the disease ... result in severe anemia ... immune hemolytic anemia ... #Workup #Hematology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
B12 (Cobalamin) Deficiency ... • Common Causes ... related to IBD, celiac ... disease, other ... total body stores Evaluation
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Discontinuation of causal ... : Chronic disease ... druginduced #lupus #sle #comparison ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Myeloproliferative Disease ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... first step in evaluation ... Thalassemia, Sickle cell anemia ... #differential #diagnosis ... #hematology
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