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differential algorithm bleeding summary thrombocytosis anemia bruising causes coagulation comparison deficiencies disorders gastroenterology gastrointestinal hemophagocytic history hlh iron lymphohistiocytosis management
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Infectious: • Acute ... disorders • Celiac ... disease Tissue ... malignancy • Iron deficiency
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Malabsorption (e.g. celiac ... disease, CF, IBD ... catastrophes, Acute ... table #comparison #diagnosis ... #hematology #deficiency
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
Gastrointestinal Evaluation ... patients with anemia, diagnose ... tests Test for celiac ... disease with serology ... #workup #diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... , deficiency anemia ... Vasculitides, IBD, Celiac ... disease, Kawasaki ... #Differential #Diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Disorders of Hemostasis ... - Differential Diagnosis ... • Warfarin • Acute ... • Acute DIC • ... #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
disrupts immune homeostasis ... • Autoimmune diseases ... Adult-onset Still disease ... Cellular immune deficiency ... inhibitors under evaluation
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
Clinical Features in Evaluating ... or factor XIII deficiency ... Disorders #History #peds ... #pediatrics #diagnosis ... #hematology #primarycare
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